Foam Granulation part 3 - muriel1carrillo02's Blog

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Foam Granulation part 3


A scholarly review at pilot-scale flow rates compared foamed-binder addition and direct liquid-injection on granulation. A methylcellulose binder was employed at two concentrations, 6% and 11%, relative to a-lactose monohydrate powder. Two screws were tested in the work to create differing axial compression characteristics with changing flow rate: one with a single couple of mixing factors developing lower axial compression and a second with two pairs in series to provide a more restrictive flow route and higher axial compression. The granule real estate from the scholarly study showed that similar sizes and intragranular porosity were achieved by either method, provided appropriate conditions were used. The reduced requirement for liquid along the way was a comparable finding to that found with high-shear batch mixers.

twin screw extruder manufacturer

Wet granulation in twin screw extrusion machinery has several key advantages over conventional methods, but to advance found in acceptance for GMP production, its operations must be better understood and challenges regarding process stableness ought to be solved. Continuous foam granulation is a fresh, robust technique that solves the process surging problems that relate with poor powder wetting by standard, liquid-addition methods. The increased spreading tendency of foam in granulation, versus the immediate soaking dynamics of liquids, produces even more uniformly wetted powders and escalates the overall lubricity of the process, which benefits use behavior of the minimizes and machine dissipative heating of the product. With comparable particle homes to standard wet granulation, foam granulation gives formulators greater flexibility in achieving production goals.

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